Pfizer researchers discuss the performance of the ExpressHT-Ultra in high-throughput DMPK studies
ExpressHT-Ultra for high speed LC/MS
Advantages of Microbore Chromatography
Low-Flow LC/MS/MS for Quantitative Bioanalysis
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handle small volume samples with unprecedented precision at flow rates from 1 nL/min to 10 µL/min and backpressures to 3,000 psi
Integrates easily into your workflow
Simple interfaces make the NanoFlow Metering System an easy plug-in solution. standard low-volume capillary fittings for connection to detectors, chips, and standard liquid handing equipment, including autosamplers.
Ideal for applications such as reagent metering for microscale combinatorial synthesis, on-chip cell manipulation, reagent addition for nanoscale protein crystallography, and flow generation and control for lab-on-a-chip applications, the NanoFlow Metering systems reliably deliver where conventional pumps fail.
Typical applications include:
Microscale synthesis
Affinity separations
Reagent addition for Nanoscale protein crystallography
Flow generation and control for lab-on-a-chip systems
Precise manipulation of cells and beads
Customized solutions
Eksigent’s flexible NanoFlow Metering platform is easily customized to meet specific requirements. Whether your application requires automation of multiple reagents added in a precise sequence, or an autosampler interface for high throughput applications, the NanoFlow System can be adapted to meet your needs. Two possible system configurations are shown below, and numerous other configurations are possible. Contact us to see how a system can be integrated easily into your microfluidics project.
features-at-a-glance
Optimized for ultra-low flow rates of 10 nL–1 µL/minute.
Precise control at low flow rates improves assay resolution.
Rapid flow response enables precise manipulation of cells and beads.
Simple interfaces allow easy incorporation with standard liquid handling equipment.
Compact size allows multiplexing to increase throughput.
Based on Eksigent’s proprietary Microfluidic Flow Control (MFC) technology.
Four individually controlled channels.
Works with conventional injection valves for sample loading, utilizing existing liquid handling equipment.
Employs standard low-volume capillary fittings for connections to detectors, chips, and other devices for quick integration into workflow.
NanoFlow Metering system specifications
channels 4 channels
flow rate range 10 nL/min to 1 uL/min,other flow rate ranges available on request.
backpressure 0 to 5,000 psi.
reagent compatibility All reagents that are compatible with 316L stainless steel and PEEK.
system control Computer with simple graphical user interface.
system outlet connections Low-volume PEEK capillary fittings.
Ideal for applications such as reagent metering for microscale combinatorial synthesis, on-chip cell manipulation, reagent addition for nanoscale protein crystallography, and flow generation and control for lab-on-a-chip applications, the NanoFlow Metering systems reliably deliver where conventional pumps fail.