Pfizer researchers discuss the performance of the ExpressHT-Ultra in high-throughput DMPK studies
ExpressHT-Ultra for high speed LC/MS
Advantages of Microbore Chromatography
Low-Flow LC/MS/MS for Quantitative Bioanalysis
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The ExpressRT™-100 system delivers meaningful reaction kinetics data for at-line reaction monitoring and real-time decision making by process chemists in reaction optimization.
If you think optimizing synthetic organic reactions is challenging, think again. The ExpressRT-100 system monitors your reactions and provides you with real-time, information-rich data. So you can better control and understand the process, prevent rejects and waste, reduce errors and shorten your production cycles. The ExpressRT-100 combines microfluidic sampling with fast microfluidic HPLC, giving you multi-dimensional reaction kinetics information before you can say, “challenging.”
Eksigent’s real-time reaction monitoring HPLC, the ExpressRT-100 system, takes samples from reaction vessels, then dilutes and injects them directly onto an HPLC. The system uses Microfluidic Flow Control technology in conjunction with a proprietary filtration system that easily accommodates high viscosity or heterogenous mixtures. The ExpressRT-100 gives you the ability to determine both conversion and percent impurity, while gaining a better understanding the kinetics of the reaction, for optimization and development of a synthetic reaction.
Features-at-a-glance
Generate real-time kinetics data for rapid decision-making.
Reduce time required to develop a synthesis.
Detect failed reactions earlier (save time, solvent and sample).
Collect samples and data overnight without an attendant.
Use advanced data processing tools to plot reaction trends, review statistics and more.
Get information-rich reaction data using only 30 µL of sample.
Filter, dilute, quench and transfer sample to HPLC automatically.
Compact design of sampling module allows you to place it near your reaction vessel and move it from reaction to reaction without effort.
Use pre-programmed dilution templates to accurately and precisely quantify a wide range of sample concentrations.
Pre-program the ExpressRT-100 to collect samples at any time-interval.
Consumes less than a fraction of a % of the solvent used in typical HPLC system.
System includes binary gradient solvent delivery, variable-volume injection and UV-absorbance detection.
Automated data processing resulting in real time generation of kinetic charts and plots.
Plot reaction trends, review statistics and perform sample quantitation using advanced data processing tools.
System control: Graphical user interface for control of all system parameters. Automated features include peak integration and creation of CDF, text, and Excel data files.
Report features: Automatic generation of printable reports including method conditions, chromatogram, peak retention, peak area, and absorbance map.
GLP features: Tracks instrument runtime, column usage, total injections, solvent usage, lamp hours, and error codes.
Dimensions
ExpressRT-100 LC analyzer (with cart): 66 cm wide, 60 cm deep, 150 cm high
ExpressRT-100 sampling module: 10 cm wide, 15 cm deep and 20 cm high
Service
The system includes a one-time installation and training.
Learn more about Eksigent’s other ExpressLC systems for pharmaceutical analysis and reaction monitoring:
ExpressLC-Ultra: State-of-the-art UHPLC with all the benefits of micro-LC that runs fast analyses with excellent reproducibility using 90% less solvent.
ExpressLC-800: A parallel HPLC system that screens eight methods simultaneously, allowing you to develop methods in 1/10th the time.
ChromXP columns: Small-scale columns designed and optimized specifically for the ExpressLC systems.
Search a list of publication citations that describe how leading scientists are using Eksigent ExpressLC systems in drug discovery and development. Or learn more about the application of Eksigent’s analytical tools in drug discovery & development:
Eksigent’s real-time reaction monitoring HPLC, the ExpressRT-100 system, takes samples from reaction vessels, then dilutes and injects them directly onto an HPLC. The system uses Microfluidic Flow Control technology in conjunction with a proprietary filtration system that easily accommodates high viscosity or heterogenous mixtures. The ExpressRT-100 gives you the ability to determine both conversion and percent impurity, while gaining a better understanding the kinetics of the reaction, for optimization and development of a synthetic reaction. 