The expressLC system delivers chiral analysis of drugs of pharmaceutical interest with efficient peaks and very low sample size requirements.
Conventional carbon-centered enantiomericity has become a major aspect of pharmaceutical drug development over the last twenty years. Although enantiomeric drug forms have long been known to exist, attention to the relative bioactivity of the enantiomers was often not addressed. More recently, drug manufacturers have investigated the pharmacological profiles of the individual isomers, and in some cases, found that the bioactivity of the drug substance could be wholly or substantially attributed to a single enantiomer.
Increased sophistication of LC chiral analysis has come to the forefront of pharmaceutical analysis, including analysis of atropisomeric (hindered rotation around a single bond) species. Often, the limited availability of pure enantiomers, high cost of convention LC columns, low peak efficiencies (and resulting high detection limits of the minor chiral species), lengthy analysis times, and frequent conversion to normal phase chromatography has made pharmaceutical chiral analysis an analytical specialty field unto itself.
The ExpressLC system delivers chiral analyses of drugs of pharmaceutical interest, often within five minutes, with efficient separations, and very low sample size requirements. The very low mobile phase volume requirements for the ExpressLC system allows analytically unique and potentially powerful chromatographic conditions unavailable in a conventional chromatography format.
Read the Application Note in its entirety.Search a list of publication citations that describe how leading scientists are using Eksigent ExpressLC systems in drug discovery and development. Or learn more about the application of Eksigent’s analytical tools in drug discovery & development:
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